Activated charcoal in tricyclic drug overdoses.

Effect of charcoal-drug ratio on antidotal efficacy of oral activated charcoal in man.

The effect of charcoal-drug ratio on the antidotal efficacy of oral activated charcoal was studied in six healthy volunteers in a randomized cross-over study and compared with the adsorption capacity of activated charcoal in vitro. Aminosalicylic acid (PAS) 1 g and 5 g were ingested on an empty stomach in 30 ml of water. Immediately afterwards the subjects ingested 50 g of activated charcoal in...

Management of drug overdoses.

Drug involvement in fatal overdoses

Death certificate data from the Multiple Cause of Death (MCOD) files were analyzed to better understand the drug categories most responsible for the increase in fatal overdoses occurring between 1999 and 2014. Statistical adjustment methods were used to account for the understatement in reported drug involvement occurring because death certificates frequently do not specify which drugs were inv...

On endocrinology and drug overdoses.

Prescription drug overdoses: a review.

PROBLEM Overdoses involving prescription drugs in the United States have reached epidemic proportions over the past 20 years. METHODS This review categorizes and summarizes literature on the topic dating from the first published reports through 2011 using a traditional epidemiologic model of host, agent, and environment. RESULTS Host factors include male sex, middle age, non-Hispanic white ...